GMP Tetanus Antitoxin Injection 1500iu/0.75ml for The Prevention of Clostridium Tetani Infection

• Customization: Available
• Application: Internal Medicine
• Usage Mode: For external use
• Model NO.: AMC14032-01
• Suitable for: Elderly, Children, Adult
• State: Liquid
• Shape: Liquid
• Type: Biological Products
• Pharmaceutical Technology: Chemical Synthesis
• OEM/ODM: Supprot
• Delivery Time: 30-60 Days
• Packing: 1500iu/0.75ml, 10′s/Box, 200 Boxes/CTN
• Transport: Shipping
• Transport Package: 10′s/Box
• Specification: 1500IU/0.75mL
• Trademark: Medipharm or OEM
• Origin: China
• HS Code: 3002909090
• Production Capacity: 5000000 Boxes/ Month

Product Description

  GMP Tetanus Antitoxin Injection 1500IU/0.75mL For the prevention of Clostridium tetani infection

Name	Tetanus Antitoxin Injection
Specidication	1500IU/0.75mL, 10's/Box, 200Boxes/CTN
Brand	Medipharm or OEM
Origin	China

 

Tetanus Antitoxin Injection

For the prevention and treatment of tetanus. When tetanus or its suspicious symptoms have occurred, antitoxin therapy should be used in time while undergoing surgical treatment and other treatments. When open wounds (especially those with deep wounds and severe pollution) are at risk of tetanus infection, preventive measures should be taken in time. Anyone who has received tetanus toxoid immunization injections should receive a booster injection of toxoid injections after injury, and no antitoxin injections are required; those who have not received toxoid immunizations or have unclear immunization history must receive antitoxin injections for prevention, but they should also be injected Simultaneously start toxoid prophylaxis for durable immunity.
Ingredients
The main components of this product: equine tetanus immune globulin digested by gastric enzymes.
This strain is a liquid antitoxin globulin preparation prepared by purifying the blood plasma obtained from horses immunized with tetanus toxoid after digestion with gastric enzymes.
Excipients: sodium chloride, m-cresol.
Finished dosage form: injection
Character
This product is a colorless or light yellow clear liquid, containing a small amount of preservatives, and a small amount of precipitate that can be shaken can be precipitated after long-term storage.
Vaccination objects - biological agents for prophylaxis
Open wounds (especially those with deep wounds and heavy pollution) are at risk of tetanus infection.
Actions and uses - biological agents for prophylaxis
This product contains specific antibodies, has the effect of neutralizing tetanus toxin, and can be used for the prevention of Clostridium tetani infection.
Indications
For the prevention and treatment of tetanus. When tetanus or its suspicious symptoms have occurred, antitoxin therapy should be used in time while undergoing surgical treatment and other treatments. When open wounds (especially those with deep wounds and severe pollution) are at risk of tetanus infection, preventive measures should be taken in time. Anyone who has received tetanus toxoid immunization injections should receive a booster injection of toxoid injections after injury, and no antitoxin injections are required; those who have not received toxoid immunizations or have unclear immunization history must receive antitoxin injections for prevention, but they should also be injected Simultaneously start toxoid prophylaxis for durable immunity.
Specification 
0.75ml, 1500IU/bottle.
Usage and Dosage
Inoculation site: subcutaneous or muscle.
Inoculation route: subcutaneous injection should be at the attachment of the deltoid muscle of the upper arm. Intramuscular injection should be in the middle deltoid muscle of the upper arm or the outer upper part of the gluteus maximus.
Dosage: Subcutaneous or intramuscular injection of 1500-3000IU once, the dosage for children and adults is the same; for severe injuries, the dosage can be increased by 1-2 times. After 5 to 6 days, if the risk of tetanus infection is not eliminated, the injection should be repeated.
Adverse reactions 
1. Anaphylactic shock: It can occur suddenly within a few minutes to tens of minutes during or after injection. The patient suddenly manifests depression or irritability, pale or flushed face, chest tightness or panting, cold sweat, nausea or abdominal pain, rapid pulse, drop in blood pressure, coma and collapse in severe cases, and can die quickly if not rescued in time. Mild cases can be relieved after injection; severe cases need infusion and oxygen infusion, use vasopressors to maintain blood pressure, and use anti-allergic drugs and adrenal cortex hormones for rescue.
2. Serum sickness: The main symptoms are urticaria, fever, enlarged lymph nodes, local edema, occasional proteinuria, vomiting, arthralgia, and erythema, itching and edema at the injection site. Generally, the onset occurs 7 to 14 days after injection, which is called the delayed type. There is also an onset 2 to 4 days after injection, which is called accelerated type. For the treatment of serum sickness, calcium or antihistamine drugs can be used, and usually it can be cured within a few days to ten days.
Taboo
Use with caution in those who have a positive reaction in the allergy test, see Desensitization Injection for details.
Precautions 
1. This product is a liquid product. Products that are turbid, have lingering precipitates, foreign objects or cracks in ampoules, unclear labels, and those that have expired and expired cannot be used. After opening the ampoule should be used up once.
2. Detailed records must be kept for each injection, including name, gender, age, address, number of injections, reaction after the last injection, results of this allergy test and reaction after injection, name and batch number of the antitoxin used, etc.
3. Injection equipment and injection sites should be strictly sterilized. The syringe should be dedicated, if not, it should be washed thoroughly after use, preferably dry-baked or autoclaved. When injecting toxoids at the same time, the syringes must be separated.
4. Special care must be taken to prevent allergic reactions when using antitoxins. An allergy test must be done before injection and the past allergy history should be inquired in detail. Those who have a history of bronchial asthma, hay fever, eczema or angioneurotic edema, or who are allergic to certain substances, or who have injected horse serum preparations in the past, should pay special attention to the occurrence of allergic reactions.
(1) Allergy test: Dilute the antitoxin 10 times with sodium chloride injection (0.1ml antitoxin plus 0.9ml sodium chloride injection), inject 0.05ml intradermally on the front palm side, and observe for 30 minutes. If there is no obvious reaction at the injection site, it is negative, and the antitoxin can be injected directly under close observation. If there are enlarged, red, swollen and infiltrated skin mounds at the injection site, especially those that look like pseudopodia or feel itchy, it is a positive reaction and must be injected with desensitization. If the injection local reaction is particularly severe or accompanied by systemic symptoms, such as urticaria, nasopharyngeal itching, sneezing, etc., it is a strong positive reaction, and the use of antitoxin should be avoided. If it must be used, desensitization injection should be used, and rescue preparations should be made. Once anaphylactic shock occurs, rescue immediately. Those with no history of allergies or those with negative anaphylaxis are not without the possibility of anaphylactic shock. For the sake of prudence, a small amount can be injected subcutaneously for testing. After observing for 30 minutes, if there is no abnormal reaction, inject the full amount subcutaneously or intramuscularly.
(2) Desensitization injection: Under normal circumstances, the antitoxin can be diluted 10 times with sodium chloride injection, subcutaneously injected in small amounts several times, and observed for 30 minutes after each injection. 0.2ml of 10-fold diluted antitoxin can be injected for the first time. When no cyanosis, wheezing or significant shortness of breath and rapid pulse are observed, the second 0.4ml can be injected. If there is still no response, the third 0.8ml can be injected. If there is still no reaction, the undiluted antitoxin in the ampoule can be injected subcutaneously or intramuscularly. Those who have a history of allergies or a strong positive allergy test should appropriately reduce the first injection amount and subsequent increments, and divide the injections into multiple injections to avoid severe reactions.
5. Outpatients must be observed for 30 minutes after injection of antitoxin before leaving.
Pharmacological effect
This product contains specific antibodies, has the effect of neutralizing tetanus toxin, and can be used for the prevention and treatment of Clostridium tetani infection.
storage
Storage: Store at 2-8°C in a dry place away from light.
Transport: 2 ~ 8 ºC dry transport away from light.
Packaging broadcast
Ampoule, 10 pieces/box.
Validity period 
36 months.