| Customization: | Available |
|---|---|
| Application: | Internal Medicine |
| Usage Mode: | For external use |
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Paracetamol(Acetaminophen):
The antipyretic and analgesic acetaminophen, this product is a metabolite of phen acetin, regulates central
prostaglandin synthase by inhibiting hypothalamic body temperature. Reduce the synthesis
and release of prostaglandin PGE1, bradykinin and histamine.
PGE1 mainly acts on the nerve center. Its decrease will lead to a decrease in the central body temperature setting point,
and the body surface temperature sensor will feel relatively hot, and then through nerve regulation,
it will cause peripheral blood vessels to dilate and sweat to achieve antipyretic effect, which inhibits the central nervous system.
The effect of prostaglandin synthesis is similar to that of aspirin, but its anti-inflammatory effect is weak.
No effect on platelets and coagulation mechanism. Indications: Used for cold and fever, joint pain, neuralgia, migraine, cancer pain and postoperative pain relief.
This product can also be used for patients who are allergic to aspirin, intolerant or not suitable for aspirin (chickenpox, hemophilia and other bleeding disorders, etc.).
Function:
1.Paracetamol is the most commonly used non-anti-inflammatory antipyretic analgesics,
antipyretic effect similar analgesic effect is weak, no anti-inflammatory anti-rheumatic effects,
acetan ilide drugs is the best varieties. Particularly suitable for patients who can not use carboxylic acids. For cold,
toothache embolism. Acetaminophen is also an intermediate for organic synthesis, hydrogenperoxide stabilizer, and photographic chemicals.
2.Paracetamol for antipyretic, analgesic, anti-rheumatic drugs
3.Paracetamol for organic synthesis intermediates, hydrogenperoxide stabilizer, photographic chemicals,
non-anti-inflammatory antipyretic analgesics.
| Testing terms | Specifications | Results |
| Appearance | A White or almost white crystalline powder,odorless,slight bitterness | Conforms |
| Solubility | Sparingly soluble in water,freely soluble in alcohol;very slightly soluble in methylenechloride | Conforms |
| Identification | Infra-red spectrum conforms to that of the reference standard. | Conforms |
| Melting point | 168-172ºC | 171ºC |
| Loss on drying | ≤0.5% | 0.08% |
| Related substances | Impurity J:4-Chloroacetanilide≤10ppm Impurity K:4-Amino phe nol≤50ppm Impurity F:4-Nitrophe nol≤0.05% Any other impurity: ≤0.05% Total of other impurity:≤0.1%ppm |
ND 1.7ppm ND 0.012% 0.025% |
| Sulfated ash | ≤0.1% | 0.04% |
| Heavy metals | ≤20ppm | <10ppm |
| Aerobic bacterial | ≤1000CFU/g | <10CFU/g |
| Mold and Yeasts | ≤100CFU/g | <10CFU/g |
| Escherichia Coli | None | None |
| Endotoxin | <0.15EU/mg | <0.15EU/mg |
| Assay | 99.0%-101.0% | 99.4% |
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