| Customization: | Available |
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| Application: | Internal Medicine |
| Usage Mode: | For oral administration |
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Amoxicillin Tablets 500mg
Indications
Acute bacterial sinusitis; Acute streptococcal tonsillitis and pharyngitis; Acute exacerbations of chronic bronchitis (AECB)/acute exacerbation of chronic obstructive pulmonary disease (AECOPD); Community acquired pneumonia;Acute otitis media; Acute cystitis; Acute pyelonephritis; Asymptomatic bacteriuria in pregnancy; Typhoid and paratyphoid fevers; Dental abscess with spreading cellulitis; Prosthetic joint infections; Helicobacter pylori eradication; Lyme disease
Dosage and Administration
Usage:Oral
Dosage: The dosage and duration of therapy should be determined by the type of infection and the response of the patient, and should generally be as short as possible.
Precautions & Warning:
1.Hypersensitivity reactions: Before initiating therapy with amoxicillin, careful enquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins or other beta-lactam agents.
2. Non-susceptible microorganisms: Amoxicillin is not suitable for the treatment of some types of infection unless the pathogen is already documented and known to be susceptible or there is a very high likelihood that the pathogen would be suitable for treatment with amoxicillin.
3.Convulsions: Convulsions may occur in patients with impaired renal function or in those receiving high doses or in patients with predisposing factors.
4.Renal impairment: In patients with renal impairment, the dose should be adjusted according to the degree of impairment
5.Skin reactions: The occurrence at the treatment initiation of a feverish generalised erythema associated with pustula may be a symptom of acute generalised exanthemous pustulosis (AGEP). This reaction requires amoxicillin discontinuation and contra-indicates any subsequent administration.
6.Jarisch-Herxheimer reaction
7.Overgrowth of non-susceptible microorganisms
8.Prolonged therapy
9.Crystalluria
10.Anticoagulants
Contraindications:
1.Hypersensitivity to the active substance, to any of the penicillins or to any of the excipients.
2.History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam).
Adverse Reactions:
1.Gastrointestinal disorders: Diarrhoea and nausea; Vomiting
2.Skin and subcutaneous tissue disorders: Skin rash;Urticaria and pruritus
3.Infections and infestations: Mucocutaneous candidiasis
4.Blood and lymphatic system disorders: Reversible leucopenia (including severe neutropenia or agranulocytosis), reversible thrombocytopenia and haemolytic anaemia.
Prolongation of bleeding time and prothrombin time
5.Immune system disorders: Severe allergic reactions, including angioneurotic oedema, anaphylaxis, serum sickness and hypersensitivity vasculitis
6.Nervous system disorders: Hyperkinesia, dizziness, convulsions; Aseptic meningitis
7.Hepatobiliary disorders: Hepatitis and cholestatic jaundice. A moderate rise in AST and/or ALT.
Renal and urinary tract disorders: Interstitial nephritis; Crystalluria
Drug interactions:
1.Probenecid: Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use of probenecid may result in increased and prolonged blood levels of amoxicillin
2.Allopurinol: Concurrent administration of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.
3.Tetracyclines: Tetracyclines and other bacteriostatic drugs may interfere with the bactericidal effects of amoxicillin.
4.Methotrexate: Penicillins may reduce the excretion of methotrexate causing a potential increase in toxicity.
Storage instructions:
Do not store above 25° C. Store in the original package and keep containers tightly closed.
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